Our lab studies aging and Alzheimer’s disease.

Vogt et al, 2020, Cerebral Cortex
Decreased cortical gray matter NODDI metrics in MCI and AD dementia groups from whole-brain analysis. From Vogt et al., 2020 published in Cerebral Cortex.

We are interested in understanding the interplay of factors that contribute to healthy or pathological brain aging. In particular, the effect of factors that contribute to or protect against the development of Alzheimer’s disease.

We use a number of tools in our research, including cognitive testing, MRIPET, and CSF analysis, to determine how risk factors for Alzheimer’s affect the brain, particularly in mid-life.

Vogt et al, 2017, Scientific Reports
13 bacterial genera identified as differentially abundant in AD were correlated with CSF biomarkers of AD including the Aβ42/Aβ40 ratio (with lower CSF levels reflecting greater amyloid deposition in the brain), phosphorylated tau (p-tau), and the p-tau/Aβ42 ratio. From Vogt et al., 2017 published in Scientific Reports.

Our NIA funded research program is focused on characterizing the early effects of Alzheimer’s disease on brain myelin and axons, in addition to determining the role of preclinical inflammation in cell and dendritic damage.

Together with collaborators both on and off of the UW campus, the lab is also studying the impact of modifiable factors that may affect trajectories of aging. These include the effect of mid-life metabolic disorders (obesity and insulin resistance), sleep, diet, and microbial influences.

Understanding early brain changes in people who may go on to develop cognitive decline is expected to lead to earlier diagnosis, prevention, and the development of new therapies for Alzheimer’s disease.

Dr. Barbara Bendlin’s Mendeley profile.

Bendlin Lab News

  • Dr. Vogt wins Jerzy E. Rose Neuroscience Award

    Former Bendlin Lab trainee Dr. Nick Vogt MD,PhD was selected as the 40th recipient of the Jerzy E. Rose Neuroscience Award for original and significant research in the neurosciences. Congratulations Dr. Vogt!

  • Congratulations Graduates!!~

    A heartfelt congratulations to all of our graduating Bendlin lab students. Best of luck with your future endeavors, and thank you for your contributions to the lab over the years! Graduate Students: Nick Vogt MD,PhD …

  • Manuscript Accepted for Publication in Neurobiology of Aging by Dr. Gilda Ennis

    Dr. Gilda Ennis, an assistant scientist in the Bendlin Lab, had her manuscript titled “The relationship of glucose-stimulated insulin secretion to cerebral glucose metabolism and cognition in healthy middle-aged and older adults” accepted for publication …

  • “Diabetes and Brain Health” – Talk by Gilda Ennis on Feb. 18 at 2PM (CST)

    Presented by Alzheimer’s Association Wisconsin Chapter and Wisconsin Alzheimer’s Institute Join us for a talk from the comfort of your home! Coffee & a Chat: Diabetes and Brain Health Gilda Ennis, PhD Coffee & a …

  • Congratulations Nick Vogt, PhD!

    Congratulations to Dr. Nick Vogt on successfully defending his thesis titled “Microbes and microstructure: using emerging technologies to better understand Alzheimer’s disease.” Nick has been a graduate student in the Bendlin Lab for the past …

  • More Bendlin Lab News posts